Additional and relevant useful information for nevus of ota. Nevus of ota a rare pigmentation disorder with intraoral. The qswitched lasers have changed the way we approach the condition and have become the mainstay of therapy. Around 50% of cases occur at birth, while the remaining occur during puberty and adulthood. The malignant neoplasm may have arisen from an area of bilateral leptomeningeal melanosis associated with unilateral nevus of ota. Very often, nevus of ota occurs unilaterally in blacks and oriental women 4. Mar 22, 2020 nevus of ota is referred to as nevi of ota in plural form. Nevus of ota or oculodermal melanocytosis is a rare congenital. Mar 26, 2019 nevus of ota, which originally was described by ota and tanino in 1939, is a hamartoma of dermal melanocytes. The efficacy of the qswitched ruby laser 694 nm, 40 nsec as a therapy for nevus of ota was investigated. Its a dermal melanocytosis seen along the distribution of ophthalmic and. Shown here is a patient with nevus of ota prior to treatment. Nevus of ota, also known as nevus fuscoceruleus opthalmomaxillaris, represents a benign partially confluent macular brownblue pigmentation of the skin and mucous membranes in the distribution of the first and second branches of the trigeminal nerve.
The nevus of ota also known as congenital melanosis bulbi and oculodermal melanocytosis is a bluegray hyperpigmentation that occurs on the face and eyes. Treatment of nevus of ota by qswitched ruby laser mayo clinic. The photo above shows significant clearance after serial. Melanocytic lesions of the cns are rare tumours originating from melanocytes that are present in the leptomeninges. It is said to be most prevalent in japan where the incidence. Comparison of characteristics of acquired bilateral. They are forms of dermal melanocytosis in which naevus cells are found deep within the dermis. Nevus of ota and nevus of ito are hyperpigmentary dermal melanocytoses which develop as a consequence of disturbances or failures during. Nevus of ota, which originally was described by ota and tanino in 1939, is a hamartoma of dermal melanocytes. Nevus support australia ia a registered not for profit, tax deductible charity, we raise funds to maintain our services and to support research into pigmented skin conditions and associated conditions including melanoma, ncm and hydrocephaly. It presents as a brown, blue, or gray patch on the face and is within the distribution of the ophthalmic and maxillary branches of the trigeminal nerve. Although intraocular and central nervous system malignant melanomas are more common in patients with nevus of ota, the prevalence is. The eyelid is darkened, pigment can be observed on the white of the eye and that iris may be darker compared to the contralateral iris. Otas nevus definition of otas nevus by medical dictionary.
We rely entirely on donations and sponsorships to maintain services to families, we are run completely by volunteers, no staff member is paid and no paid. Information and translations of nevus of ota in the most comprehensive dictionary definitions resource on the web. Only 11 cases have been documented in the english literature. The nevi develop from melanocytes, which are the cells in the bottom layer of the epidermis, or the skins outer layer. Glaucoma in oculodermal melanocytosis ophthalmology. Individuals with nevus of ota experience emotional and psychosocial distress related to cosmetic disfigurement and often look for treatment.
Nevus of ota neelam n redkar1, kavita j rawat2, siddharth warrier 3, anurag jena4 n evus of ota noo also known as congenital melanosis bulbi, 1 nevus fuscoceruleus, ophthalmomaxillaris, oculodermal melanocytosis2 and oculomucodermal melanocytosis. The nevus of ota appears as increased pigmentation of one eye and its eyelids. Nevus of ota nevus fuscocoeruleus ophthalmomaxillaris or ocular dermic melanocytosis is a clinical condition characterized by bluedark pigmentation, greenblue, violet, or tan spots in the eyes andor on the faces skin and lids. Nevus of ota is caused when melanocytes the cells that produce the skins pigment, melanin become trapped in the dermis the middle layer of the skin nevus of ota involves the first two branches of the trigeminal nerve which is the nerve that allows us to bite, chew and feel sensation in the face. Nevus of ota is mostly unilateral and located around the oral mucosa and mucous of the eye. Some degree of lightening can be achieved with lasers. Nevus of ota and nevus of ito are uncommon sporadic forms of dermal melanocytosis. Clinically, nevus of ota presents as a blue or gray patch on the face, which is congenital or acquired and is within the distribution of the ophthalmic and maxillary branches of. Nevus of ota typically presents as unilateral blueblack or slate gray macules that are located in the distribution of the first or second branches of the trigeminal nerve figure 1. Nevus of ito is less common than nevus of ota, although the true incidence is unknown.
They may be associated with capillary malformations. Nevus of ota is caused by the entrapment of melanocytes in the upper third of the dermis. Yag are described, confirming the efficacy as well as safety of this treatment for nevus of ota. A small group of these tumours have histopathological features between those of a benign melanocytoma and a malignant melanoma. Sebastiao cronemberger1, nassim calixto1, henrique leite. Nevus of ota is a dermal melanocytosis originally described by ota and tanino in 1939. The nevus of ota is a dermal nevus characterized by bluish.
Moreover, traditional treatments are largely palliative or risk permanent pigmentary changes andor scarring. Among these, nevus of ota and abnom are clinically similar and both diseases cause aesthetic problems as they develop on the face and are not selflimited. A case of unilateral nevus of ota was associated with ipsilateral ocular melanocytosis and contralateral malignant melanoma of the cns. Nevus of ota is a hyper pigmentation birthmark that causes a blue coloured bruiselike patch to form on the skin, specifically on the face. Nevus of ota with contralateral cerebral melanoma jama. Primary meningeal melanocytoma of the cerebellopontine. Isolated cases of delayedonset acquired nevi of ota that first appear in adults, including in older patients, have been reported 3. Naevus of ota, naevus of ito and naevus of hori are special melanocytic naevi that have a slatebrown or bluegrey colouring. Aug 20, 2014 nevus of ota originally described as nevusfuscocaeruleus ophthalmomaxillaris by ota and tanino in 1939 is a dermal melanocytosis most commonly found in japanese 1,2. Pdf nevus of ota clinicalophthalmological findings researchgate. Mar 26, 2019 nevi of ota and ito occur most frequently in individuals of asian descent, with an estimated prevalence of 0. Cases a case 1 the first patient presented with a nevus of ota on the left side of the face, showing discoloration which was more pronounced around the eye socket and. Jan 21, 2015 nevus of ota and nevus of ito are uncommon sporadic forms of dermal melanocytosis.
Naevus of ota, naevus of ito and naevus of hori dermnet nz. Nevus of ota is caused when melanocytes the cells that produce the skins pigment, melanin become trapped in the dermis the middle layer of the skin nevus. The condition is more common in females, with a malefemale ratio of 1. Nevus of ota is referred to as nevi of ota in plural form. Ce syndrome inhabituel a ete decrit en 1938 par ota qui lavait alors denomme naevus fuscocaeruleus ophthalmomaxillaris 2. Isolated cases of delayedonset acquired nevi of ota that first appear in adults, including in older patients, have been reported. The association of an intracranial intermediategrade melanocytic neoplasm with a nevus of ota is extremely rare, with only 2 cases reported in the literature to date. As a result, their behavior and progression are still poorly understood. Patients with the nevus of ota should be examined at least every 6 months by an eyecancer specialist and a neurologist. Clinically, nevus of ota presents as a blue or gray patch on the face, which is congenital or acquired and is within the distribution of the ophthalmic and maxillary branches of the trigeminal nerve. Intracranial intermediategrade melanocytic neoplasm. Nevus of ota is most commonly found in asians and affects around 0.
Comparison of characteristics of acquired bilateral nevusof. Nevus of ota, a dermal melanocytic nevus, is rare in the indian subcontinent. It presents as a brown, blue, or gray patch on the face and is within the distribution of the ophthalmic and maxillary. In rare cases malignant melanoma may develop in the skin or the uvea. Pdf a 40 yearold male presented to the department of ophthalmology of a. Ota, known by the pen name mokutaro kinoshita, was a japanese doctor who first described the condition in 1939, which is why it is named after him. More accurately grouped with dermal melanocytoses nevus of ito, nevus of ota, hori nevus, socalled mongolian spot emedicine nevi of ota and ito although melanocytic, it is not a true nevus different entity from hypomelanosis of ito, a neurocutaneous disorder j. Nevus of ota is a blue hyperpigmentation that occurs on the face, most often appearing on the white of the eye. Neurofibromatosis associated with nevus of ota and choroidal melanoma. Classification, nevus of ota, laser therapy, pigmentation. Women are nearly five times more likely to be affected than men. More accurately grouped with dermal melanocytoses nevus of ito, nevus of ota, hori nevus, socalled mongolian spot emedicine nevi of ota and ito although melanocytic, it is not a true nevus different entity from hypomelanosis of ito, a neurocutaneous disorder j child neurol 2000. The oral cavity is infrequently involved in nevus of ota. Request pdf nevus of ota the nevus of ota is a hypermelanotic melanocytic phacomatosis, characterised by.
Clinically, nevus of ota is distributed along the ophthalmic and maxillary divisions of the trigeminal nerve and presents as a blue or gray patch on the face. They consist of a spectrum of pigmented tumours ranging from melanocytoma to melanoma. It should not be confused with mongolian spot, which is a birthmark caused. To analyze the clinical and ophthalmological findings of patients with nevus of ota. Differential diagnosis for skin lesions of nevus of ota includes. The first case of phakomatosis pigmentovascularis figure 6 was described in 1920 in a patient with generalized hemangioma and nevus. Ota, a japanese physician, in 1939, and hence the term nevus of ota. Nevus of ota originally described as nevusfuscocaeruleus ophthalmomaxillaris by ota and tanino in 1939 is a dermal melanocytosis most commonly found in japanese 1,2. A complete clearance of otas nevus after treatment with golden. Oculodermal melanocytosis, also known as nevus of ota, is a condition of excessive pigmentation of the uvea, sclera, episclera, and eyelids secondary to an increase in the number of normal melanocytes. The sclera is involved in twothirds of cases causing an increased risk of glaucoma. Hyperpigmentation of parts of the eye may occur sclera. Nevus of ota is a benign dermal melanocytic nevus that typically affects asian children and women. A nevus of ota with intraoral involvement international journal of.
It also occurs on the forehead, nose, cheek, periorbital region, and temple. It is found only on the face, most commonly unilaterally, rarely bilaterally and involves the first two branches of the trigeminal nerve. Most patients seek treatment early in life due to the psychological trauma and cosmetic disfigurement. The nevus presents as unilateral bluegray hyperpigmented macules and patches scattered along the first and second divisions of the trigeminal nerve. The first case of phakomatosis pigmentovascularis figure 6 was described in 1920 in a patient with. Retrospective analysis of patients charts with nevus of ota. Naevus of ota is on the forehead and face around the eye area.
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